IVI RMA Global Education

Master degree online in the Biotechnology of Human Assisted Reproduction and Embriology

IVI RMA Global Education

1 Años
5.500 €


This Master provides students with a highly advanced theoretical understanding of human reproductive biology; embryology; fertility mechanisms and the causes of infertility; the techniques employed to overcome this by using cutting-edge assisted reproductive technology (ART) as well as state-of-the-art research techniques applied in different circumstances to the study and treatment of human sterility.

More than 50 experts with clinical, teaching and research experience of more than 20 years who work in all areas of the prestigious Instituto Valenciano de Infertilidad (Valencian Institute of Infertility, IVI), where over 25,000 assisted reproduction treatments are performed a year, share their extensive knowledge, skills and experience to provide students with the most up-to-date theoretical information. This program is aimed at recent graduates with a Degree in Biomedical Sciences and also at professionals working in this area who wish to refresh their knowledge so as to provide their patients with the best possible attention and assistance on offer today.

During the past few decades there has been a growing demand for assisted reproduction techniques in both developed and developing countries. This is usually as a result of the advanced maternal age of first time mothers, harmful life habits and diverse genetic and environmental factors.

This has led to a notable increase in the number of infertile patients needing to be treated, a boom of new assisted reproduction units and the consequent need for trained professionals in all areas concerned with reproductive medicine, especially laboratories, the real black-box  of assisted reproduction success. This area is also one of the most dynamic in medicine, where new advances are constantly taking place, leading to the need for a constant upgrade of knowledge and techniques applicable to infertility diagnosis and treatments.

Biomedical sciences professionals must remain updated about the best available knowledge for every circumstance. Although much of this knowledge can be found in different international forums, such as meetings or congresses, there are almost no regulated studies involving both the essential training elements for every professional working in reproductive medicine added to the dynamism of the most recent findings and procedures.


There are also tutorials for continuous assessment that will be used to verify to what extent the students have assimilated the information, and also to take standardized tests, explore practical cases and explain essay questions, etc. which are all intertwined in the contents and related to the most important aspects of the course.

This set of activities will be tutored and assessed by the corresponding professors. The program will end with a dissertation based on writing a review and a bibliographical research paper that will afford a deeper knowledge of the contents.

The Virtual Classroom enables a close relationship between students and professor and also provides a dynamic way to teach. This service is compatible with all web browsers and operating systems, and students will have a personal code to log on to the online course.

Virtual education allows access to lifelong learning, breaking the barriers of space and time, and allows students to easily combine their daily activities and personal obligations with their educational interests, so providing training anytime, any place and anywhere.

The communication between the participants on the course takes place on forums that allow them to share files and messages. The aim of these forums is to be a meeting point for all the students and professors, allowing discussions about current aspects related to the program contents, to bring up any doubts of a general nature and to pass on the publication of press articles related to the subject-matter, etc.

The virtual classroom service has a videoconferencing system for meetings, webcasts and webinars. Students will also have one of the professors appointed as their personal tutor for any other type of consultation.

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Human reproduction physiology.
1. Pelvic anatomy
2. Steroid hormones
3. Effects of ageing
4. Neuroendocrinology of the reproductive axis
5. Folliculogenesis and ovulation
6. Hormones of the reproductive system
7. Endocrinology of the testicle
8. Obesity and endocrine axes.
9. Menstrual vs. Estrous cycle.

Oogenesis, spermatogenesis and their deficiencies
1. Biological relevance of the meiosis
2. Ovogenesis
3. Folliculogenesis
4. Ovulation induction
5. Spermatogenesis and sperm production
6. Markers of sperm quality
7. Factors affecting sperm quality
8. Markers of oocyte quality
9. Oocyte maturation
10. in vitro gamete derivation from human embryonic stem cells.

Fertilization, embryo development and techniques to obtain in vivo produced embryos
1. Fertiization and embryo development
2. Gamete maturation
3. Fertilization, fertilization anomalies and uniparental inheritances
4. Embryo development
5. Main landmarks in embryo development.

1. Polycystic ovary syndrome
2. Sterility
3. Cervical and immune sterility
4. Uterine and tubal sterility
5. Endometriosis
6. Artificial insemination and in vitro fertilization
7. Repeated miscarriage
8. Egg donation
9. Ovulation induction
10.Special cases in IVF
11. Ovarian and endometrial manipulation

Basic research in assisted reproduction
1. Basic research in assisted reproduction
2. Nucleic acids
3. Separation techniques
4. Microscopy
5. vitro studies
6. Microarrays
7. Bioinformatics
8. ERA
9. Massive sequencing
10.Culture of human granulosa cells
11. Animal models for the study of the ovarian 
12. hyperstimulation syndrome and endometriosis
13. Lipidomics

Basic techniques in assisted reproduction
1. Structure of an AR unit
2. History of the ART
3. Diagnostic procedures in the clinical analysis laboratory
4. Low complexity techniques
5. High complexity procedures
6. Donation of gametes
7. Applied molecularbiology techniques
8. Research in AR

Andrology laboratory
1. The testicle and the spermatogenesis
2. Semen analysis
3. Sperm preparation techniques for conjugal artificial insemination
4. Application of image analysis in sperm
5. Sperm freezing techniques
6. Selection of donors
7. Management and control of the sperm bank
8. Reproductive treatment in HIV-seropositive males
9. Flow cytometry in sperm
10. Sperm DNA fragmentation
11. Methods for an objective selection
12. Microarrays
13. Other molecular markers of sperm quality.

In vitro fertilization laboratory 
1. Embryology Laboratory
2. Oocyte retrieval and insemination
3. Micromanipulation techniques
4. Evaluation of fertilization
5. Oocyte dysmorphisms
6. Standard embryo culture
7. Cryopreservation of oocytes and embryos
8. Quality management in the embryology laboratory

Sex determination techniques
1. Animal sexing
2. Analysis of the sperm DNA content
3. Legislation according to sex determination
4. Molecular bases of sex determination
5. Sexual differentiation in humans
6. Advantages of sexual reproduction
7. Relevance of preconception and preimplantation 8. sex selection in humans
9. Alterations in the sex ratio

In vitro production of embryos. Embryo culture
1. Cell culture
2. Culture media
3. Embryo development
4. Types of prolonged cultures
5. The blastocyst
6. Application of embryo co-culture in research

Cryobiology. Preservation of maternal and paternal inheritance. Embryo preservation.
1. Principles of physics
2. Water dynamics
3. Dynamics of water with solutes
4. Dynamics of solution with cells
5. Cryoprotectants
6. Cryopreservation: balance
7. Cryopreservation: non-balance
8. Cryopreservation of maternal and paternal inheritance
9. Cryopreservation of ovarian tissue

Embryo quality improvement
Morphological parameters
2. Non-morphological parameters 
3. Improvement of embryo quality
4. Intrinsecal factors affecting embryo quality: effect of the spermatozoon
5. Intrinsecal factors affecting embryo quality: effect of the oocyte
6. Extrinsecal factors affecting embryo quality
7. Ex vivo culture conditions
8. Nuclear and cytoplasmic transfer
9. Assisted hatching and aspiration of fragments

Multiplication of embryos and gametes
1. Embryo cloning without reprogramming
2. Embryo cloning by means of nuclear transfer
3. Methodology
4. Reversibility of the differentiated status
5. Applications
6. Multiplication of gametes

Preimplantation genetic screening laboratory
1. Origin of aneuploidies
2. Chromosomal alterations in the infertile couple and genetic counseling
3. Genetic studies in the infertile couple
5. Embryo biopsy
6. PGD for the screening of aneuploidies
7. PGD for structural chromosomal anomalies
8. Relation between embryo morphology and chromosomal anomalies 
9. Correction of aneuploidies
10. PGD for the screening of monogenic diseases
11. PGD for HLA matching
12. PGD by means of massive sequencing

Stem cells
1. Stem cells
2. Pluripotent cell. Human Embryonic Stem Cells:
Derivation, culture and characterization
3. Reprogramming: iPSC
4. Cancer stem cells
5. Adult stem cells
6. Umbilical cord blood bank
7. Adult stem cells in human testicles
8. Adult stem cells in human ovaries
9. Somatic stem cells in the endometrium
10. Somatic stem cells in the myometrium
11. Differentiation of gametes
12. Bioethics and legislation

Legal ethical considerations of assisted human reproduction.
Legal ethical considerations of assisted human reproduction.
Initial conceps
Ethical aspects of the application of the TRA: bioethics
Law of autonomy of the patient
Research in assisted reproduction.

Final master work.
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Course intended for Graduates in Biomedical Sciences (Biologists, Doctors, Veterinarians, Pharmacists and similar groups).


The training is provided through the online training platform.


Start date: october 2018.

Lugar donde se imparte el curso

Aula Virtual IVI


The program will accredit graduates to pursue a career in the human assisted reproduction field, genetic diagnosis and/or research in reproductive science.

Titulación obtenida

Máster propio de la Universidad de Valencia. Organizado por el Instituto Valenciano de Infertilidad IVI.
Master's degree managed by ADEIT from the University of Valencia.


5.500 €

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Master degree online in the Biotechnology of Human Assisted Reproduction and Embriology

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Master degree online in the Biotechnology of Human Assisted Reproduction and Embriology